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Dr. Ho Chun Loong’s research focuses primarily on using synthetic biology and protein engineering to address various health and environmental issues. This includes establishing a platform where researchers could share their constructs and systematically amass these genetic constructs for protein engineering purposes.
Dr. HO CHUN LOONG was born in Malaysia. The research direction mainly focuses on utilizing synthetic biology and protein engineering to solve various health and environmental problems, including establishing a platform that enables researchers to share and systematically collect gene structures for protein engineering purposes. In 2013, he obtained a doctoral degree in biochemistry from Nanyang Polytechnic University in Singapore and studied under Professor Liang Zhao xun. He was engaged in the production of secondary metabolites using multi-module polyketide synthase methods and the design of proteins as biosensors for tracking the intracellular signaling molecules of bacteria, cyclic di-GMP, at the level of scientific research. Subsequently, he conducted postdoctoral research at the SyncTI Center for Clinical and Technological Innovation in Synthetic Biology at the National University of Singapore, focusing on the design of proteins that can confer therapeutic functions on probiotics and symbiotic microorganisms. The research results have been published multiple times in journals such as Nature Biomedical Engineering, Journal of American Chemistry Society, and ACS Synthetic Biology, with over 200 citations and 6 patent applications.
Contact：
Email: cl.ho@siat.ac.cn
Link: http://synmicrobiome.org/
Publications/Patents (selected)
1. Pan, Y.,^ Chua, N.Y.,^ Lim, K.S., and Ho, C.L.*, Engineering of Human Lactoferrin for Improved Anticancer Activity. ACS Pharmacology and Translational Sciences, 2021, 4(5): 1476–1482.
2. Ho CL, Tan HQ, Chua KJ, Kang A, Lim KH, Ling KL, Yew WS, Thiery JP, Chang MW. Engineered commensal microbes for diet-mediated colorectal-cancer chemoprevention. Nature Biomedical Engineering, 2018, 2, 27-37.
3. Lubkowicz D^, Ho CL^, Lee YS, Chang MW. Reprogramming probiotic Lactobacillus reuteri as a biosensor for detecting Staphylococcal quorum sensing. ACS Synthetic Biology. 2018, 7(5):1229-1237.
4. Liu, Z., Chen, Z., Cui, B., Wang, Y., Lim, K., Li, K., Thiery, J.P., Chen, J., and Ho, C.L.*, Targeted EpCAM-binding for the development of potent and effective anticancer proteins. Biomedicine and pharmacotherapy, 2023, 161, 114443.
5. Liu, F., Li, J., Zhang, T., Chen, J., and Ho, C.L.*, Engineering Spore-Forming Bcillus as a Microbial Vessel for Long-Term DNA Data Storage. ACS Synthetic Biology, 2022, 2022, 11 (11) 3583–3591.
6. Ho C.L., Pan Y, Chua NY. 乳铁蛋白活性肽及其应用. Chinese Patent: 202110656090.X
7. Chang MW, Ho CL. Engineered Therapeutic Probiotic System and Method. US Patent: US2019/0209625 A1
8. Liang ZX, Sun HH, Ho CL. A polyketide synthase construct and its use in the preparation of polyketides. US Patent: WO2013/172782 A1