The development of genomics over the past decades has given us more comprehensive and in-depth understanding of the genetic information of various organisms, thus opens up a treasure trove of valuable genetic information. Synthetic genomics emerges, and it aims to systematically dissect the biological function of a genome, and create new features for various practical applications through re-design, re-construction, and de novo synthesis of the entire genome.Through precise design and accurate synthesis of the genome, master the basic principle of biological systems, reveal the essence of life activities, and eventually accomplish the strategic transformation of life science from qualitative to quantitative prediction, precise design, standardized synthesis and precise regulation.
Rebuild plant metabolites biosynthesis pathways in plant-based systems.
The regulation mechanism of epigenetic inheritance; Epigenetic inheritance regulation; The synthetic epigenome-related technologies.
1. Mode of action of artemisinin; 2. Metal homeostasis and diseases in Drosophila models;
Focused on the non-coding genome using various systems. Particular interests include identifying functional non-coding regions during development and under disease conditions, dissection of non-coding genome function by genome redesign and synthetic genomes.
Nanobiosensors, Pseudovirus system, and Single-virus tracking.
Systems Biology
Focus on developing novel chemical tools or probes for nucleic acid biology.
Systematically investigate genome plasticity through evolutionary strategies.
The research interest lie in synthetic biology using different model organisms, focusing on development of new technologies for genes synthesis, assembly and synthetic genomics.
Protein chemistry, bioorganic chemistry and chemical biology
Design and synthesis of plant artificial chromosomes
Regulation of secondary metabolism in plants and Plant Metabolomics