Dr. Yingfei Ma's research focus is on the virome and synthetic biology of phage. Phage is the most abundant and diverse group of biological entities on the planet. The vast majority of the phage in nature are uncultured. Due to the progress in sequencing technology, the newest culture-independent way of assessing phage diversity and abundance is using viral metagenomics. The Ma lab is developing new bioinformatics tools using cutting-edge techniques, such as machine learning, deep learning, etc., to identify phage sequences from the complex microbial metagenomics sequencing data. The identification of new phage sequences will help us understand the role of phage in a give ecosystem. Meanwhile, For more than a century,phage research has enabled some of the most important discoveries in biological sciences. Phages have also been recognized and exploited as natural antimicrobial agents. Recent progress in DNA manipulation and synthetic biology allowed scientists to engineer phage genomes. This may have the potential to accelerate the construction of designing phage genomes with superior therapeutic potential.
TEL：0755-86392674
EMAIL：yingfei.ma@siat.ac.cn
WEBSITE：http://isynbio.siat.ac.cn/malab
Publications/Patents (recent)
Ling Chen#, Jiqiang Fan#, Tingwei Yan, Quan Liu, Shengjian Yuan, Haoran Zhang, Jinfang Yang, Deng Deng, Shuqiang Huang* and Yingfei Ma*, Isolation and Characterization of Specific Phages to Prepare a Cocktail Preventing Vibrio sp. Va-F3 Infections in Shrimp (Litopenaeus vannamei), 2019, Front. Microbiol., 11 October 2019, https://doi.org/10.3389/fmicb.2019.02337
Guoqin Mai, Limei Chen, Ran Li, Quan Liu, Haoran Zhang, and Yingfei Ma, 2019. Common Core Bacterial Biomarkers of Bladder Cancer Based on Multiple Datasets, BioMed Research International, vol. 2019, Article ID 4824909, 8 pages, https://doi.org/10.1155/2019/4824909.
L. Chen, G. Guan, Q. Liu, S. Yuan, T. Yan, L. Tian, Y. Zhou, Y. Zhao, Y. Ma, T. Wei*, X. Fu*. 2019. Characterization and complete genomic analysis of two Salmonella phages, SenALZ1 and SenASZ3, new members of the genus Cba120virus. Archives of Virology.
Jinming Cui#, Guoqin Mai#, Zuowei Wang, Quan Liu, Yan Zhou,Yingfei Ma* and Chenli Liu*, 2019. Metagenomic insights into a cellulose-rich niche reveal microbial cooperation in cellulose degradation. Front. Microbiol.28 March
Ling Chen, Shengjian Yuan, Quan Liu, Guoqing Mai, Jinfang Yang, Deng Deng, Bingzhao Zhang, Chenli Liu and Yingfei Ma*. In vitro design and evaluation of phage cocktails against Aeromonas salmonicida. Front. Microbiol. 2018