Xiang GAOAssociate Professor

The Gao group is interested in exploring semiconductor-cell biointerface.

Xiang Gao is currently a Principal Investigator at Materials Synthetic Biology Center, Shenzhen Institute of Synthetic Biology (iSynBio). Dr. Gao received his PhD in Microbiology from Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences under the supervision of Prof. Chen Yang. During his PhD study, he utilized metabolomics and 13C dynamic flux analysis to guide the engineering terpenoids biosynthetic pathway in cyanobacteria and E. coli. He conducted his postdoctoral research at the University of Chicago under the supervision of Prof. Bozhi Tian, where he developed structured semiconductor as a new tool to modulate microbial activity and discovered a rapid electrical signaling in microbial system. Then he worked as postdoc at the National Renewable Energy Lab (NREL), where he designed synthetic one carbon metabolites utilization pathway in microorganism using semiconductor-bacteria hybrid system. His works were published in Nat. Biomed. Eng., Energy Environ. Sci., Nat. Protoc., Sci. Adv., Adv. Mater., and Metab. Eng. etc. Since Nov. 2020, he stated his lab in iSynBio, focus on developing novel platform to modulate bacteria, and nano-enabled strategies to enhance the performances of microbial system in biomanufacturing. 

EMAIL: gaoxiang@siat.ac.cn

LINK: http://isynbio.siat.ac.cn/gaolab/

Publications/Patents (recent)

Gao X, Jiang Y, Lin Y, Kim H, Fang Y, Yi J, Meng L, Lee H, Lu Z, Leddy O, Zhang R, Tu Q, Feng W, Nair V, Griffin P, Shi F, Shekhawat G, Dinner, Park H, Tian B. Structured silicon for revealing transient and integrated signal transductions in microbial systems. Science Advances 6: aay2760. 2020.

Gao X, Gao F, Liu D, Zhang D, Nie X, Yang C. Engineering methylerythritol phosphate pathway in cyanobacteria for photosynthetic isoprene production from CO2. Energy & Environmental Science 9: 1400-1411. 2016.

Jiang Y, Parameswaran R, Li X, Carvalho-de-Souza J, Gao X, Meng L, Bezanilla F, Shepherd G, Tian B. Nongenetic optical neuromodulation with silicon-based materials. Nature Protocols 14: 1339–1376. 2019.

Jiang Y, Li X, Liu B, Yi J, Fang Y, Shi F, Gao X, Sudzilovsky E, Parameswaran R, Koehler K, Nair V, Yue Y, Guo K, Tsai H, Freyermuth G, Wong R, Kao C, Chen C, Nicholls A, Wu X, Shepherd G, Tian B. Rational design of silicon structures for optically controlled multiscale biointerfaces. Nature Biomedical Engineering 2: 508-521. 2018.

Feng W, Han X, Wang R, Gao X, Hu P, Yue W, Chen Y, Shi J. Nanocatalysts-augmented and photothermal‐enhanced tumor-specific sequential nanocatalytic therapy in both NIR-I and NIR-II biowindows. Advanced materials 31: 1805919. 2019.