Dr. Li is interested in understanding the mechanisms underlying bacterial-based tumor therapies and the immune exclusion in cancer, by combining computational modeling and quantitative data analysis.
Dr. Xuefei Li received his Ph.D. in 2012 at Department of Physics, HKBU. During his Ph.D., Dr. Li focused on theoretical studies of bacteria metabolism and bacterial-based cancer therapy. He stayed in HKBU as a Postdoctoral Research Fellow after graduation for three years (2012-2015), and then joined the Center for Theoretical Biological Physics Rice University as a Postdoctoral Research Fellow. At Rice University (2015-2019), Dr. Li focused on the tumor microenvironment and had 4 first-author papers on this topic, including 2 PNAS papers. In his work, via data analysis and computational modeling studies, Dr. Li proposed a repellent-dominated mechanism to explain the infiltration pattern of cytotoxic immune cells, which could be helpful to improve the immune therapy. In July 2019, Dr. Li joined Shenzhen Institutes of Advanced Technology as an Associate Professor. Dr. Li's expertise includes theoretical modeling of biological systems and quantitative analysis of biological data.
EMAIL: xuefei.li@siat.ac.cn
WEBSITE: http://isynbio.siat.ac.cn/Li(x)lab/
Publications/Patents (selected)
Xuefei Li#, Tina Gruosso#, Dongmei Zuo, Atilla Omeroglu, Sarkis Meterissian, Marie-Christine Guiot, Adam Salazar, Morag Park*, Herbert Levine*. Infiltration of CD8+ T cells into tumor cell clusters in triple-negative breast cancer. PNAS 2019, 116(9):3678-3687
Xuefei Li#, Mohit Kumar Jolly#, Jason T. George, Kenneth J. Pienta, Herbert Levine*. Computational modeling of the crosstalk between macrophage polarization and tumor cell plasticity in the tumor microenvironment. Frontiers in Oncology 2019, 9:10;
Xuefei Li#, Rajesh Balagam#, Ting-Fang He, Peter P. Lee, Oleg A. Igoshin*, Herbert Levine*, On the mechanism of long-range orientational order of fibroblasts. PNAS 2017, 114(34):8974-8979
Xuefei Li and Herbert Levine*. Bistability of the cytokine-immune cell network in a cancer microenvironment. Convergent Science Physical Oncology 2017, 3(2): 024002.
Dongya Jia, Xuefei Li, Federico Bocci, Shubham Tripathi, Youyuan Deng, Mohit Kumar Jolly*, José N. Onuchic*, and Herbert Levine*. Quantifying cancer epithelial-mesenchymal plasticity and its association with stemness and immune response. Journal of Clinical Medicine 2019, 8(5): 725.
Bin Yu, Mei Yang, Lei Shi, Yandan Yao, Qinqin Jiang, Xuefei Li, Lei-Han Tang, Bo-Jian Zheng, Kwok-Yung Yuen, David K. Smith, Erwei Song, and Jian-Dong Huang. Explicit hypoxia targeting with tumor suppression by creating an “obligate” anaerobic Salmonella Typhimurium strain. Scientific Reports 2012, 2: 436