Dr. Chunbo Lou is an Investigator of Shenzhen Institute of Advanced Technology, CAS. He obtained his Ph.D. in biophysics from Peking University in 2009, and started his postdoctoral research with Prof. Chris Voigt at UCSF and MIT. He joined Institute of Microbiology, CAS from 2013, and moved to Shenzhen from 2019. He has designed and constructed complex genetic circuits and fundamental design principles for genetic programming. His lab is currently developing high-quality regulatory parts for mammalian genetic circuit, and predictably design complex spatial-temporal control circuits for vaccine engineering, tissue engineering and precise expression in engineering stem cell and cancer cells.
EMAIL: cb.lou@siat.ac.cn
Publications/Patents (recent)
Miao, C., Zhao, H., Qian, L., & Lou, C. (2019). Systematically investigating the key features of the DNase deactivated Cpf1 for tunable transcription regulation in prokaryotic cells. Synthetic and Systems Biotechnology, 4(1), 1-9.
Zheng, Y., Meng, F., Zhu, Z., Wei, W., Sun, Z., Chen, J., Lou, C*. & Chen, G. Q*. (2019). A tight cold-inducible switch built by coupling thermosensitive transcriptional and proteolytic regulatory parts. Nucleic acids research, 47(21), e137-e137.
Li, T., Dong, Y., Zhang, X., Ji, X., Luo, C., Lou, C., & Ouyang, Q*. (2018). Engineering of a genetic circuit with regulatable multistability. Integrative Biology, 10(8), 474-482.
Hou, J., Zeng, W., Zong, Y., Chen, Z., Miao, C., Wang, B., & Lou, C*. (2018). Engineering the Ultrasensitive Transcription Factors by Fusing a Modular Oligomerization Domain. ACS synthetic biology, 7(5), 1188-1194.
Tang Q, Lou C*, Liu SJ*. Construction of an easy-to-use CRISPR-Cas9 system by patching a newly designed EXIT circuit. Journal of biological engineering, 2017, 11(1): 32.
Synthetic Biology Tools, Chunbo Lou, Tae Seok Moon, Virgil Rhodius, Brynne Stanton, Alvin Tamsir, Karsten Temme and Christopher Voigt, U.S. Patent Application No. 13/489,205.：PCT/US2012/040939; WO 2012/170436.A1
Methods and Kits for Fragmenting DNA, Ting F. Zhu, Yuval Ebenstein, Chunbo Lou, Wenjun Jiang, Xuejin Zhao, Tslil Gabrieli, U.S. Patent Application No. 62/156,417; PCT/IL2016/0503394.; WO 2016/178207.A1
Novel Oligo-linker-mediated DNA Assembly Method and Applications Thereof. Chunb Lou, Yong Tao, Xuejin Zhao, Shasha Zhang, Lihua Zhang, Chunhua Zhai, Zhenyu Liu, U.S. Patent Application US2016/0340670. A1
基于CRISPR/Cas9和酿酒酵母细胞内源的同源重组的分子克隆方法，娄春波，赵学金， 发明专利CN 105624146,专利号ZL 2015 1 0282184.X
构建生产或高产目的基因产物重组菌的方法及构建的重组菌与应用, 张立新;胡逸灵;娄春波;白超弦;苗靳;向四海;黄佩;, 发明专利CN105176899A