Gaowen LIUAssociate Professor

Systematically investigate genome plasticity through evolutionary strategies

Gaowen Liu received her Master degree in 2012 from National University of Singapore (NUS) for her study of epigenetic regulation of FLC locus in Arabidopsis of Dr. Yuehui He at the Temasek life science Laboratory (TLL).  She then joined the group of Dr. Giulia Rancati at Institute of Medical biology, A*STAR to systematically study adaptive evolution of budding yeast to the deletion of essential genes, where she published first author paper in CELL and received her PhD in 2016 from Nanyang Technological University in Singapore (NTU). She obtained postdoctoral training in the laboratory of Dr. Sophie Martin at University of Lausanne in Switzerland, studying fusion efficiency evolution to the deletion of essential mating genes. She received prestigious Long-term postdoctoral fellowship from Human Frontier Science Project (HFSP) for her postdoctoral training. She won Ray Wu prized, national excellent oversea student award and Kaluza prize finalist in 2016. She is now an associate professor in Shenzhen Institute of Advance technology, institute of synthetic biology.

Contact:+86-0755-86715297
Email: gaowen.liu@siat.ac.cn

Website: http://www.gaowenliulab.blog 


Publications/Patents (selected)

Liu G, Yong M, Yurieva M, K. G. Srinivasan, Liu J, Lim J, Poidinger M, Wright G, Zolezzi F, Choi H, Pavelka N, Rancati G. Gene essentiality is a quantitative property linked to cellular evolvability. Cell. 2015 163(6):1388-99         

Liu G, Rancati G. Adaptive Evolution: Don’t Fix What’s Broken. Current Biology. 2016 Volume 26, Issue 4, Pages R169-R171                    

Camattari A, Goh A, Yip LY, Tan AH, Ng SW, Tran A, Liu G, Liachko I, Dunham MJ, Rancati G. Characterization of a panARS-based episomal vector in the methylotrophic yeast Pichia pastoris for recombinant protein production and synthetic biology applications. Microb Cell Fact 15, 139 (2016)    

Vjestica A, Marek M, N’kosi P, Merlini L, Liu G, Berard M, Billault-Chaumartin I, Martin SG. A toolbox of Stable Integration Vectors (SIV) in the fission yeast Schizosaccharomyces pombe. Journal of Cell Science. 2020 133: jcs240754

Vjestica A, Bérard M, Liu G, Merlini L, N’kosi P, Martin SG. Cell cycle-dependent and independent mating blocks ensure fungal zygote survival and ploidy maintenance. PLOS Biology .2021