Yu Chen, professor. He obtained a doctor's degree in biochemical engineering at ECUST in 2018, subsequently conducted post-doc research with Jens Nielsen in Sweden, and joined Institute of Synthetic Biology at SIAT of CAS in 2023. Research focus is on systems and synthetic biology, including developing metabolic models and integrating dry and wet technologies to accurately simulate cellular behaviors and guide rational engineering and artificial synthesis of cells. In the past five years, he has published first-author papers in PNAS (4 papers), Nature Protocols, Molecular Systems Biology, Nucleic Acids Research and other journals; co-authored papers in Cell, Nature Catalysis, Nature Chemical Biology and other journals. He has been invited to serve as reviewer of PNAS, Nature Communications, Bioinformatics and other journals for many times. Current fundings are from the Shenzhen Medical Research Fund, the National Key Research and Development Program of China and the Shenzhen Science and Technology Program.
Email: y.chen3@siat.ac.cn
Link：https://chenyu.website/
Publications/Patents (selected)
Reconstruction, simulation and analysis of enzyme-constrained metabolic models using GECKO Toolbox 3.0. Nature Protocols (2024)
Yeast has evolved to minimize protein resource cost for synthesizing amino acids. Proceedings of the National Academy of Sciences (2022)
In vitro turnover numbers do not reflect in vivo activities of yeast enzymes. Proceedings of the National Academy of Sciences (2021)
Yeast optimizes metal utilization based on metabolic network and enzyme kinetics. Proceedings of the National Academy of Sciences (2021)
Proteome constraints reveal targets for improving microbial fitness in nutrient-rich environments. Molecular Systems Biology (2021)
Energy metabolism controls phenotypes by protein efficiency and allocation. Proceedings of the National Academy of Sciences (2019)