基于物种相互作用，结合大数据分析和多组学技术，解码自然界的“化学”语言，发掘药物先导化合物。
石一鸣研究员，博士生导师。毕业于中国科学院昆明植物研究所药物化学专业。获洪堡基金的资助于德国歌德法兰克福大学开展博士后研究工作，后获马普陆地微生物研究所聘任为Project Group Leader。部分研究成果已发表在Nature Chemistry、Nature Chemical Biology、Nature Microbiology和Angewandte Chemie,等期刊上。
联系邮箱：ym.shi@siat.ac.cn
个人网站：https://sym-lab.net/
主要科研成果
[1] Shi, Y.-M.*; Hirschmann, M.; Shi, Y.-N.; Ahmed, S; Abebew, D.; Tobias, N. J.; Grün, P.; Crames, J. J.; Pöschel, L.; Kuttenlochner, W.; Richter, C.; Herrmann, J.; Müller, R; Thanwisai, A; Pidot, S. J.; Stinear, T. P.; Groll, M; Kim, Y.; Bode, H. B.* Global analysis of biosynthetic gene clusters reveals conserved and unique natural products in entomopathogenic nematode-symbiotic bacteria. Nat. Chem. 2022, 14, 701-712
[2] Shi, Y.-M.*#; Crames, J. J.#; Czech, L.; Bozhüyük, K. A. J.; Shi, Y.-N.; Hirschmann, M.; Lamberth, S.; Paczia, N.; Rückert, C.; Kalinowski, J.; Bange, G.; Bode, H. B.* Genome mining enabled by biosynthetic characterization uncovers a widespread class of benzoxazolinate-containing natural products. Angew. Chem. Int. Ed. 2022, 61, e202206106.
[3] Shi, Y.-M.*; Hirschmann, M.; Shi, Y.-N.; Bode, H. B.* Cleavage off-loading and post-assembly-line conversions yield products with unusual termini during biosynthesis. ACS Chem. Biol. 2022, 17, 2221-2228
[4] Shi, Y.-M.; Brachmann, A. O; Westphalen, M. A.; Neubacher, N.; Tobias, N. J.; Bode, H. B.*, Dual phenazine gene clusters enable diversification during biosynthesis. Nat. Chem. Biol. 2019, 15, 331-339.
[5] Wang, G.#; Zhao Z.#; Ke, J.#; Engel, Y.#; Shi, Y.-M.#; Zhang, Z.; Bingol, K.; Robinson, D.; Wang, B.; Evans, R.; Miyamoto, Y.; Cheng, K.; Bowen, B.; Louie, K.; Kosina, S.; de Raad, M.; Silva, L.; Luhrs, A.; Lubbe, A.; Hoyt, W. D.; Francavilla, C.; Otani, H.; Deutsch, S.; Washton, M. N.; Rubin, E. M.; Mouncey, N. J.; Visel, A.; Cheng, J.-F.; Northen, T.; Bode, H. B.*; Yoshikuni, Y.* Chassis-independent recombinase-assisted genome engineering enables rapid activation of biosynthetic gene clusters in undomesticated bacteria. Nat. Microbiol. 2019, 4, 2498-2510
(*corresponding author; #equal contribution).