NK细胞与肿瘤免疫微环境/肿瘤免疫干预靶点的寻找与药物研发
郑小虎，博导，中国科学技术大学教授，国家基金委优青获得者（2021），安徽省杰青获得者（2021）。着力于肿瘤组织微环境中NK细胞免疫监视功能丢失的机制研究，寻找新型免疫干预靶点，形成逆转或激活NK细胞功能的免疫治疗策略。相关成果以通讯作者和第一作者发表在Nat Immunol、PNAS、Cancer Res、Clinic Cancer Res、Nati Sci Rev和Cell Mol Immunol等学术期刊。
联系邮箱：ustczxh@ustc.deu.cn
论文发表节选
Xiaohu Zheng, Yeben Qian, Binqing Fu, Defeng Jiao, Yong Jiang, Peng Chen, Yiqing Shen, Huafeng Zhang, Rui Sun, Zhigang Tian* and Haiming Wei *, Mitochondrial fragmentation limits natural killer cell-based tumour immunosurveillance. Nature Immunology, 2019 Dec, 20;1656-1667.
Xiaohu Zheng, Fan X, Fu B, Zheng M, Zhang A, Zhong K, Yan J, Sun R, Tian Z*, Wei H*, EpCAM inhibition sensitizes chemoresistant leukemia to immune surveillance. Cancer Research, JAN 15 2017, 77; 482-493.
Xiaohu Zheng, Min Cheng, Binqing Fu, Xiaolei Fan, Qing Wang, Xiaoqing Yu, Rui Sun, Zhigang Tian*, Haiming Wei*. Targeting LunX inhibits non-small-cell lung cancer growth and metastasis. Cancer Research, March 15, 2015 75; 1080-90.
Jiacheng Bi, Chaoyue Zheng and Xiaohu Zheng*. Increased expression of adenosine A3 receptor in tumor-infiltrating natural killer cells. Cell Mol Immunol. 2021, DOI: 10.1038/s41423-020-00632-1.
Zhigang Nian, Xiaohu Zheng*, Yingchao Dou, Xianghui Du, Li Zhou, Binqing Fu, Rui Sun, Zhigang Tian, Haiming Wei*, Rapamycin pretreatment rescues the bone marrow AML cell elimination capacity of CAR-T cells, Clinic Cancer Research, 2021, DOI: 10.1158/1078-0432.