自动化合成生物学和数据驱动合成生物化学研究。
司同，研究员，清华大学化生基科班学士，伊利诺伊大学香槟分校化工博士。课题组关注工程生物学前沿技术的开发，包括自动化合成生物技术、高通量质谱筛选、数据驱动合成生物化学研究等，用于燃料、药物、精细化工品等重要分子的发现、研究与生产。曾获国家优秀自费留学生、美国化工协会AIChE年会分会场主席等荣誉。成果发表在Nature Communications, JACS, Metabolic Engineering等国际著名学术期刊。
联系方式：0755-86585243
联系邮箱：tong.si@siat.ac.cn
个人网站：http://isynbio.siat.ac.cn/sitonglab/
论文发表节选
Tong Si#, Qiqi Tian#, Yuhao Min, Linzixuan Zhang, Jonathan V. Sweedler, Wilfred A. van der Donk*, Huimin Zhao*, Rapid screening of lanthipeptide analogs via in colony removal of leader peptides in Escherichia coli, J. Am. Chem. Soc., 140(38), 11884-11888 (2018)
Tong Si#, Bin Li#, Troy J. Comi#, Yuwei Wu, Pingfan Hu, Yuying Wu, Yuhao Min, Douglas A. Mitchell, Huimin Zhao*, Jonathan V. Sweedler*, Profiling of microbial colonies for high-throughput engineering of multi-step enzymatic reactions, J. Am. Chem. Soc., 139(38), 12466-12473 (2017)
Tong Si, Ran Chao, Yuhao Min, Yuying Wu, Wen Ren, Huimin Zhao*, Automated multiplex genome-scale engineering in yeast, Nat. Commun., 8, 15187 (2017)
Tong Si#, Bin Li#, Ke Zhang, Yiran Xu, Huimin Zhao*, Jonathan V. Sweedler*, Characterization of Bacillus subtilis colony biofilms via mass spectrometry and fluorescence imaging, J. Proteome Res., 15, 1955-1962 (2016)
Tong Si#, Han Xiao#, Huimin Zhao*, Rapid prototyping of microbial cell factories via genome-scale engineering, Biotech. Adv., 33, 1420-1432 (2015)
成果转化节选
Combinatorial Design of Highly Efficient Heterologous Pathways, Huimin Zhao, Byongjin Kim, Jing Du, Yongbo Yuan, Dawn Eriksen, Tong Si, US2011/054650