合成微生物组的设计和调控
戴磊博士，中国科学院深圳先进技术研究院研究员、博士生导师，深圳合成生物学创新研究院微生物组研究中心主任。国家重点研发计划青年项目首席科学家，入选《麻省理工科技评论》中国区“35岁以下科技创新35人”。实验室利用合成生物学的工具，对微生物组的结构和功能进行理性设计和精准调控，致力于解决人体健康、农业生产等重大问题。研究成果以第一作者或通讯作者发表在Science、Nature、PNAS、eLife等国际学术期刊。
联系方式：0755-86392436
联系邮箱：lei.dai@siat.ac.cn
论文发表节选
Hongbin Liu #, Chen Liao #, Lu Wu , Jinhui Tang, Junyu Chen, Chaobi Lei, Linggang Zheng, Chenhong Zhang, Yang-Yu Liu, Joao Xavier, Lei Dai*. Ecological dynamics of the gut microbiome in response to dietary fiber. ISME Journal (2022)
Linggang Zheng,# Yang Tan,*,# Yucan Hu, Juntao Shen, Zepeng Qu, Xianbo Chen, Chun Loong Ho, Elaine Lai-Han Leung, Wei Zhao, and Lei Dai*. CRISPR/Cas-Based Genome Editing for Human Gut Commensal Bacteroides Species.ACS Synthetic Biology (2022)
Ying Wang, Jinhui Tang,Qingqing Lv,Yuxiang Tan, Xiaoxiao Dong, Hongbin Liu, Nannan Zhao, Zhen He,Yan Kou,Yan Tan, Xin-an Liu,Liping Wang,Yang-Yu Liu, and Lei Dai*, Establishment and resilience of transplanted gut microbiota in aged mice. iScience (2021)
Du, Y., Xin, L., Shi, Y., Zhang, T., Wu, N.C., Dai, L., Gong, D., Brar, G.,Shu,S., Luo, J., Reiley, W., Tseng, Y., Bai, H., Wu, T., Wang, J., Shu, Y., Sun, R. Genome-wide identification of interferon-sensitive mutations enables influenza vaccine design. Science (2018)
Du, Y.*, Zhang, T.*, Dai, L.*, Zheng, X.*, Gorin, A., Oishi, J., Wu, T., Yoshizawa J.M., Li, X., Yang O.O.,Martinez, O., Detels, R., Sun, R. 1. Effects of mutations on replicative fitness and MHC-I binding affinity are among the determinants underlying CTL escape of HIV-1 Gag Epitopes. mBio (2017)