肿瘤免疫和免疫治疗/ 调节性B细胞在自身免疫性疾病和肿瘤中的作用及机制研究
储以微，复旦大学教授，长期从事肿瘤免疫与免疫生物治疗，炎癌转化的免疫学机制研究，以及B淋巴细胞与免疫调节。在肿瘤放化疗后体内免疫系统重建及机制、TLRs抗肿瘤免疫效应及机制研究、以及肿瘤疫苗和CART设计等方面取得系列发现，研发了快速DC疫苗、第四代CART细胞免疫治疗技术。主持和参与多项国家和省部级项目，包括国家自然科学基金重点项目、面上项目、国家重点研发计划等。在国内外学术刊物上发表论文 251 篇，申请或授权专利10余项。主编规划教材《免疫学与病原生物学》,《医学免疫学》，以及人卫出版社英文教材《Medical Immunology》等。
联系邮箱：Yiwei_chu@126.com
论文发表节选
Wanwei Zheng, Huan Song, Zhongguang Luo, Hao Wu, Lin Chen, Yuedi Wang Haoshu Cui, Yufei Zhang, Bangting Wang, Wenshuai Li, Yao Liu, Jun Zhang, Yiwei Chu*, Feifei Luo*, Jie Liu*. Acetylcholine ameliorates colitis by promoting IL-10 secretion of monocytic myeloid-derived suppressor cells through the nAChR/ERK pathway. PNAS. 2021 118(11):e2017762118
Qian J, Luo F, Yang J, Liu J, Liu R, Wang L, Wang C, Deng Y, Lu Z, Wang Y, Lu M, Wang JY, Chu Y*.TLR2 Promotes Glioma Immune Evasion by Downregulating MHC Class II Molecules in Microglia. Cancer Immunol Res. 2018 6(10):1220-1233.
Qian J#, Wang C#, Wang B, Yang J, Wang Y, Luo F, Xu J, Zhao C, Liu R, Chu Y*.The IFN-γ/PD-L1 axis between T cells and tumor microenvironment: hints for glioma anti-PD-1/PD-L1 therapy. J Neuroinflammation. 2018 15(1):290(1-13)
Liu R, Lu Z, Gu J, Liu J, Huang E, Liu X, Wang L, Yang J, Deng Y, Qian J, Luo F, Wang Z, Zhang H, Jiang X, Zhang D, Qian J, Liu G, Zhu H, Qian Y, Liu Z, Chu Y*. MicroRNAs 15A and 16-1 Activate Signaling Pathways That Mediate Chemotaxis of Immune Regulatory B cells to Colorectal Tumors. Gastroenterology. 2018;154(3):637-651
Lu Z, Liu J, Liu X, Huang E, Yang J, Qian J,3, Zhang D, Liu R*, Chu Y*. MiR-15a/16-1 Suppresses AHR-dependent IL-22 Secretion in CD4+ T cells and Contributes to Immune-mediated Organ Injury.Hepatology. 2017 ; 67(3):1027-1040