病毒感染及防治研究的新策略和新系统。
司龙龙博士，中国科学院深圳先进技术研究院合成生物学研究所研究员、博士生导师。入选国家高层次人才（青年）、深圳市高层次人才。博士毕业于北京大学，在哈佛大学Wyss研究所、哈佛医学院完成博士后研究工作。实验室主要研究方向为“病毒感染及防治研究的新策略和新系统的开发及应用”，包括人体器官体外仿生系统“人体器官芯片”、新型病毒疫苗技术、抗病毒药物的开发。发表论文40余篇，其中代表性研究成果以通讯作者、第一作者（含共同一作）发表于Science、 Nature Biotechnology、Nature Biomedical Engineering、 Nature Communications、Science Advances等专业期刊，申请和授权专利20余项，合作开发的一个抗新冠药物已申请进入临床II期试验。部分研究工作获 “中国科学十大进展”、“国际疫苗学会-年度论文”、Wyss Technology Development Fellowship等荣誉奖励。
联系邮箱：ll.si@siat.ac.cn
课题组网站：http://isynbio.siat.ac.cn/SILAB/
发表文章节选
Si L#, Bai H#, Rodas M, Cao W, Oh CY, Jiang A, Moller R, Hoagland D, Oishi K, Horiuchi S, Uhl S, Blanco-Melo D, Albrecht RA, Liu WC, Jordan T, Nilsson-Payant BE, Golynker I, Frere J, Logue J, Haupt R, McGrath M, Weston S, Zhang T, Plebani R, Soong M, Nurani A, Kim SM, Zhu DY, Benam KH, Goyal G, Gilpin SE, Prantil-Baun R, Gygi SP, Powers RK, Carlson KE, Frieman M, tenOever BR, Ingber DE*. A human-airway-on-a-chip for the rapid identification of candidate antiviral therapeutics and prophylactics. Nature Biomedical Engineering 2021. https://doi.org/10.1038/s41551-021-00718-9 (#co-first author, *corresponding author)
Si L#, Bai H#, Oh CY, Jin L, Prantial-Baun R, Ingber DE*. Clinically relevant influenza virus evolution reconstituted in a human lung airway-on-a-chip. Microbiology Spectrum 2021. (#co-first author, *corresponding author)
Si L, Meng K, Tian Z, Sun J, Li H, Zhang Z, Soloveva V, Li H, Fu G, Xia Q, Xiao S, Zhang L, Zhou D*. Triterpenoids manipulate a broad range of virus-host fusion via wrapping the HR2 domain prevalent in viral envelopes. Science Advances 2018; 4: eaau8408.
Si L#, Xu H#, Zhou X, Zhang Z, Tian Z, Wang Y, Wu Y, Zhang B, Niu Z, Zhang C, Fu G, Xiao S, Xia Q, Zhang L, Zhou D*. Generation of influenza A viruses as live but replication-incompetent virus vaccines. Science 2016; 354: 1170-1173. (#co-first author, *corresponding author)
Xiao S#*, Si L#, Tian Z, Jiao P, Fan Z, Meng K, Zhou X, Wang H, Xu R, Han X, Fu G, Zhang Y, Zhang L, Zhou D*. Pentacyclic triterpenes grafted on CD cores to interfere with influenza virus entry: A dramatic multivalent effect. Biomaterials 2016; 78: 74-85. (#co-first author, *corresponding author)