解析与调控肿瘤微环境以改进肿瘤免疫治疗
李雪飞，博士，副研究员。研究领域主要包括，生物数据的定量与自动化分析，以及从定量生物数据出发，进行数理模型的构建与分析。研究课题主要围绕肿瘤微环境中的生物学和物理学。主要代表性工作之一是通过定量分析肿瘤切片图像数据，刻画淋巴毒性T细胞在肿瘤中的空间分布，并根据定量数据，构建了合理的数学物理模型以解释分布机理，从而为提升免疫治疗效果提供了理论指导。另外，通过构建合理的物理模型，揭示了肿瘤内成纤维细胞环绕肿瘤规则排列的机制，为扫除限制药物、免疫细胞浸润的物理屏障提供了理论指导。作为合成院内以理论研究为主的课题组，李博士将致力于合成院内理论与实验联合研究的平台建设。
联系邮箱：xuefei.li@siat.ac.cn
个人网址：http://isynbio.siat.ac.cn/Li(x)lab/
发表文章节选
Xuefei Li#, Tina Gruosso#, Dongmei Zuo, Atilla Omeroglu, Sarkis Meterissian, Marie-Christine Guiot, Adam Salazar, Morag Park*, Herbert Levine*. Infiltration of CD8+ T cells into tumor cell clusters in triple-negative breast cancer. PNAS 2019, 116(9):3678-3687
Xuefei Li#, Mohit Kumar Jolly#, Jason T. George, Kenneth J. Pienta, Herbert Levine*. Computational modeling of the crosstalk between macrophage polarization and tumor cell plasticity in the tumor microenvironment. Frontiers in Oncology 2019, 9:10;
Xuefei Li#, Rajesh Balagam#, Ting-Fang He, Peter P. Lee, Oleg A. Igoshin*, Herbert Levine*, On the mechanism of long-range orientational order of fibroblasts. PNAS 2017, 114(34):8974-8979
Xuefei Li and Herbert Levine*. Bistability of the cytokine-immune cell network in a cancer microenvironment. Convergent Science Physical Oncology 2017, 3(2): 024002.
Dongya Jia, Xuefei Li, Federico Bocci, Shubham Tripathi, Youyuan Deng, Mohit Kumar Jolly*, José N. Onuchic*, and Herbert Levine*. Quantifying cancer epithelial-mesenchymal plasticity and its association with stemness and immune response. Journal of Clinical Medicine 2019, 8(5): 725.