赵国屏博士/名誉中心主任

微生物组群落结构与宿主代谢组学的关联分析,微生物宏基因组、菌种泛基因组。

赵国屏,博士,研究员,中国科学院院士,任中国科学院深圳先进技术研究院合成生物学研究所首席科学家。研究领域包括微生物代谢调控及酶的结构功能与反应机理,开发相应的微生物多组学分析技术。主持了若干重要微生物基因组和功能基因组研究,完成了对重要致病菌钩端螺旋体的全基因组测序和注释,鉴定若干关键代谢途径和功能基因,为深入研究其致病机理提供新的思路。主持了SARS分子流行病学和SARS冠状病毒的进化研究,为认识该病毒的动物源性及其从动物间传播到人间传播过程中基因组、特别是关键基因的变异规律奠定了基础。中国科学院微生物组研究计划的学术带头人和微生物组大数据平台建设的积极推动者,致力于微生物组研究的技术标准化和组学大数据资源的挖掘和平台化。

联系电话:021-54924000 

联系邮箱:gpzhao@sibs.ac.cn

个人网页:http://isynbio.siat.ac.cn/zhaolab/

http://www.sippe.ac.cn/klsb/cp5_zhaogp.asp


论文发表节选

Peng Li; Hong Zhang; Guoping Zhao*; Wei Zhao*; Deacetylation enhances ParB-DNA interactions affecting chromosome segregation in Streptomyces coelicolor, Nucleic Acids Research, 2020. (PMID: 32313947)

Lin Zheng#;Shuo Chen#;Fochang Wang;Shiying Huang; Xinhui Liu;Xilan Yang;Haokui Zhou;Guo-Ping Zhao;Mingjing Luo*;Shunmin Li*; Jianping Chen*;Distinct Responses of Gut Microbiota to Jian-Pi-Yi-Shen Decoction Are Associated With Improved Clinical Outcomes in 5/6 Nephrectomized Rats,Frontiers in Pharmacology,2020,11.

Liao Tianhua# ; Wei Yuchen# ; Luo Mingjing; Zhao Guo-Ping *; Zhou Haokui*;tmap: an integrative framework based on topological data analysis for population-scale microbiome stratification and association studies, Genome Biology, 2019, 20(1). (PMID:31870407)

Hong Zhang; Peng Li; Shuangxi Ren; Zhongyi Cheng;Guoping Zhao *;  Wei Zhao *; ScCobB2-mediated lysine desuccinylation regulates protein biosynthesis and carbon metabolism in Streptomyces coelicolor, Molecular & Cellular Proteomics, 18(10):2003-2017. 2019. (PMID: 31337674)

Xiaobiao Han#; Liqiang Shen#; Qijun Wang; Xufeng Cen; Jin Wang; Meng Wu; Peng Li; Wei Zhao *; Yu Zhang*; Guoping Zhao *Cyclic AMP inhibits the activity and promotes the acetylation of acetyl-CoA synthetase through competitive binding to the ATP/AMP pocket, Journal of Biological Chemistry, 292:1374-1384. 2017. (PMID: 27974467)