翟冰博士/研究员

利用系统生物学与合成生物学方法,研究病原真菌的耐药机制和致病机制,关注人体微生物群落中真菌与细菌的互作关系及其对疾病发生、进展产生的影响。

翟冰博士,中科院深圳先进技术研究院合成生物学研究所研究员,本科毕业于中国农业大学生物科学专业,博士毕业于美国Texas A&M University生物系,之后在纽约Memorial Sloan Kettering Cancer Center从事博士后研究。研究成果发表在Nature Medicine, Nature Microbiology等期刊。

  

联系邮箱:bing.zhai@siat.ac.cn

实验室网站: zhailabs.wordpress.com



论文发表节选

1. Fan Y, Wu L, Zhai B*. The mycobiome: interactions with host and implications in diseases. Curr. Opin. Microbiol. 2023 75, 102361.

2. Zhai B#,*, Liao C#, Jaggavarapu S#, Tang Y#, Rolling T, Ning Y, Sun T, Bergin SA, Gjonbalaj M, Miranda E, Babady NE, Taur Y, Butler G, Zhang Li, Xavier JB, Weiss DS*, Hohl TM*. “Echinocandin heteroresistance causes prophylaxis failure and facilitates breakthrough Candida parapsilosis infection.” medRxiv (# equal contribution)

3. Rolling T#, Zhai B#, Gjonbalaj M, Tosini N, Yasuma-Mitobe K, Fontana E, Amorett LA, Wright RJ, Ponce DM, Perales MA, Xavier JB, van den Brink MRM, Markey KA, Peled JU, Taur Y, Hohl, TM. Intestinal fungal dynamics and linkage to hematopoietic cell transplantation outcomes. Nat. Microbiol. 2021 6 (12), 1505-1515. (# equal contribution)

4. Zhai B, Ola M, Rolling T, Tosini NL, Joshowitz S, Littmann ER, Amoretti LA, Fontana E, Wright RJ, Miranda E, Veelken CA, Morjaria SM, Peled JU, van den Brink MRM, Babady NE, Butler G, Taur Y, and Hohl TM. High-resolution mycobiota analysis reveals dynamic intestinal translocation prior to invasive candidiasis. Nat. Med. 2020 Jan;26, 59-64.

5. Drummond RA, Swamydas M#, Oikonomou V#, Zhai B#, Dambuza IM, Brian C Schaefer BC, Bohrer AC, Mayer-Barber KD, Lira SA, Iwakura Y, Filler SG, Brown GD, Hube B, Naglik JR, Hohl TM, Lionakis MS. CARD9+ microglia promote antifungal immunity via IL-1β-and CXCL1-mediated neutrophil recruitment. Nat. Immunol. 2019 May;20(5):559. (# equal contribution)