In order to solve the bottlenecks in tumor treatment of bacteria and photothermal nanomaterials, Lintao Cai and Chenli Liu of Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences collaborated to use synthetic anaerobic targeting of Salmonella as a carrier to load nanoparticles and transfer organisms. The combination of the directional advantages of bacteria and the efficacy of inorganic bodies (nanoparticles) achieves the directional aggregation and killing of photothermal nanomaterials in tumors, providing new ideas for the treatment of solid tumors. The article was published online on May 24, 2019 under the title "Nanophotosensitizer-engineered Salmonella bacteria with hypoxia targeting and photothermal-assisted mutual bioaccumulation for solid tumor therapy".
Figure. Schematic of Salmonella-coupled Photothermal Nanoparticles and Combined Treatment
Fuming Chen, Zhongsheng Zang and Ze Chen are the co-first authors; Lintao Cai, Liu Chenli and Mingbin Zheng are co-corresponding authors.
Original link: https://www.sciencedirect.com/science/article/pii/S0142961219303230?via=ihub